Formation of a functional hepatitis B virus replication initiation complex involves a major structural alteration in the RNA template.

@article{Beck1998FormationOA,
  title={Formation of a functional hepatitis B virus replication initiation complex involves a major structural alteration in the RNA template.},
  author={Juergen Beck and Michael Nassal},
  journal={Molecular and cellular biology},
  year={1998},
  volume={18 11},
  pages={6265-72}
}
The DNA genome of a hepatitis B virus is generated by reverse transcription of the RNA pregenome. Replication initiation does not involve a nucleic acid primer; instead, the hepadnavirus P protein binds to the structured RNA encapsidation signal epsilon, from which it copies a short DNA primer that becomes covalently linked to the enzyme. Using in vitro-translated duck hepatitis B virus (DHBV) P protein, we probed the secondary structure of the protein-bound DHBV epsilon RNA (Depsilon) and… CONTINUE READING

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