Formation of a distinct connexin43 phosphoisoform in mitotic cells is dependent upon p34cdc2 kinase.

@article{Lampe1998FormationOA,
  title={Formation of a distinct connexin43 phosphoisoform in mitotic cells is dependent upon p34cdc2 kinase.},
  author={Paul D Lampe and Wendy E. Kurata and Bonnie J. Warn-Cramer and Alan F. Lau},
  journal={Journal of cell science},
  year={1998},
  volume={111 ( Pt 6)},
  pages={833-41}
}
The gap junction protein connexin43 is a phosphoprotein that typically migrates as three bands (nonphosphorylated, P1 and P2) during polyacrylamide gel electrophoresis. The electrophoretic mobility of connexin43 from mitotic cells was distinctly reduced to a form (P3) that migrated slower than P2 from Rat1 cells prepared by shakeoff of nocodazole-treated and untreated cultures. Mitotic FT210 cells, which contain a temperature-sensitive mutation in the p34(cdc2) kinase, showed abundant levels of… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 32 extracted citations

Similar Papers

Loading similar papers…