Formation of a cationic gold(I) complex and disulfide by oxidation of the antiarthritic gold drug auranofin.

@article{Mohamed2003FormationOA,
  title={Formation of a cationic gold(I) complex and disulfide by oxidation of the antiarthritic gold drug auranofin.},
  author={A. Ait Mohamed and Jinhua Chen and Alice E. Bruce and M. R. Bruce and Jeanette A Krause Bauer and David T Hill},
  journal={Inorganic chemistry},
  year={2003},
  volume={42 7},
  pages={2203-5}
}
The mechanism of action of auranofin, an antiarthritic gold(I) drug, is unknown, but several studies suggest that oxidation may be important for its biochemical effect. Bulk electrolysis studies on auranofin [(Et(3)P)Au(TATG); TATG = 2,3,4,6-tetraacetyl-1-thio-d-glucopyranosato] at +1.2 and +1.6 V versus Ag/AgCl in 0.1 M Bu(4)NBF(4)/CH(2)Cl(2) results in n values of 0.5 and >2 electrons, respectively. Oxidation of auranofin with the mild oxidant, Cp(2)Fe(+), results in formation of disulfide… CONTINUE READING