Formation of a Polycomb-Domain in the Absence of Strong Polycomb Response Elements

@inproceedings{De2016FormationOA,
  title={Formation of a Polycomb-Domain in the Absence of Strong Polycomb Response Elements},
  author={Sandip De and Apratim Mitra and Yuzhong Cheng and Karl Pfeifer and Judith A. Kassis},
  booktitle={PLoS genetics},
  year={2016}
}
Polycomb group response elements (PREs) in Drosophila are DNA-elements that recruit Polycomb proteins (PcG) to chromatin and regulate gene expression. PREs are easily recognizable in the Drosophila genome as strong peaks of PcG-protein binding over discrete DNA fragments; many small but statistically significant PcG peaks are also observed in PcG domains. Surprisingly, in vivo deletion of the four characterized strong PREs from the PcG regulated invected-engrailed (inv-en) gene complex did not… CONTINUE READING
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