Formation of Supramolecular Structures between DNA and Starburst Dendrimers Studied by EPR, CD, UV, and Melting Profiles

Abstract

Poly(amidoamine) starburst dendrimers (SBDs) form stable supramolecular structures (complexes) with DNA and confer protection against degradation by nucleases. Such properties make SBDs excellent candidates for application in gene delivery strategies. Formation of supramolecular structures by two generations of SBDs, namely 2SBD and 6SBD, with calf thymus… (More)

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