Formation of LID vector complexes in water alters physicochemical properties and enhances pulmonary gene expression in vivo

@article{Jenkins2003FormationOL,
  title={Formation of LID vector complexes in water alters physicochemical properties and enhances pulmonary gene expression in vivo},
  author={Rosalind G. Jenkins and Q-H Meng and Rebecca J Hodges and Li Kim Lee and Stephen E. W. Bottoms and Geoffrey John Laurent and Dianna Willis and Parviz Ayazi Shamlou and Robin J McAnulty and Stephen L Hart},
  journal={Gene Therapy},
  year={2003},
  volume={10},
  pages={1026-1034}
}
There is currently an urgent need to develop efficient gene-delivery systems for the lung that are free of inflammatory effects. The LID vector is a synthetic gene delivery system, comprised of lipofectin (L), an integrin-targeting peptide (I) and DNA (D) that has previously been shown to have high transfection efficiency in the lung. We have assessed the effect of alternative methods of complex preparation on structural features of the complex, levels and duration of reporter gene expression… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 10 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 37 references

The effect of dosing interval on reporter gene expression in mouse lung

  • D Gill, I Pringle, L Davies, S. Hyde
  • Mol Ther
  • 2001

A controlled trial of intratumoral ONYX-015, a selectively replicating adenovirus, in combination with cisplatin and 5-fluorouracil in patients with recurrent head and neck cancer

  • FR Khuri
  • Nat Med
  • 2000

Similar Papers

Loading similar papers…