Formation of Extrachromosomal Circular DNA from Long Terminal Repeats of Retrotransposons in Saccharomyces cerevisiae

@article{Mller2015FormationOE,
  title={Formation of Extrachromosomal Circular DNA from Long Terminal Repeats of Retrotransposons in Saccharomyces cerevisiae},
  author={Henrik Devitt M{\o}ller and Camilla Eggert Larsen and Lance L. Parsons and Anders Johannes Hansen and Birgitte Regenberg and Tobias Mourier},
  journal={G3: Genes|Genomes|Genetics},
  year={2015},
  volume={6},
  pages={453 - 462}
}
Extrachromosomal circular DNA (eccDNA) derived from chromosomal Ty retrotransposons in yeast can be generated in multiple ways. Ty eccDNA can arise from the circularization of extrachromosomal linear DNA during the transpositional life cycle of retrotransposons, or from circularization of genomic Ty DNA. Circularization may happen through nonhomologous end-joining (NHEJ) of long terminal repeats (LTRs) flanking Ty elements, by Ty autointegration, or by LTR–LTR recombination. By performing an in… 
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