Formation of Cyclohepta[b]indole Scaffolds via Heck Cyclization: A Strategy for Structural Analogues of Ervatamine Group of Indole Alkaloid.

@article{Goswami2015FormationOC,
  title={Formation of Cyclohepta[b]indole Scaffolds via Heck Cyclization: A Strategy for Structural Analogues of Ervatamine Group of Indole Alkaloid.},
  author={Progyashree Goswami and A. Borah and P. Phukan},
  journal={The Journal of organic chemistry},
  year={2015},
  volume={80 1},
  pages={
          438-46
        }
}
Ervatamine, silicine, methuenine, etc., are naturally occurring alkaloids that exhibit antimicrobial, anticancer, and anti-HIV activities. Indole fused with a seven-membered carbocyclic ring is a commonly observed structural feature among this series of bioactive compounds. This work describes a strategic approach for the synthesis of cyclohepta[b]indole structural scaffolds. The synthetic strategy consists of a solvent-free Baylis-Hillman reaction of 2-bromobenzaldehydes, followed by iodine… Expand
14 Citations
Cyclohepta[b]indoles: A Privileged Structure Motif in Natural Products and Drug Design.
New syntheses of cycloalka[b]indoles
...
1
2
...

References

SHOWING 1-10 OF 57 REFERENCES
...
1
2
3
4
5
...