Formation of 8-nitroguanine by the reaction of guanine with peroxynitrite in vitro.

@article{Yermilov1995FormationO8,
  title={Formation of 8-nitroguanine by the reaction of guanine with peroxynitrite in vitro.},
  author={Vladimir Yermilov and Julieta Rubio and Michel Becchi and Marlin D. Friesen and Brigitte Pignatelli and Hiroshi Ohshima},
  journal={Carcinogenesis},
  year={1995},
  volume={16 9},
  pages={2045-50}
}
Nitric oxide and superoxide anion, both formed in inflamed tissues, react rapidly to form the peroxynitrite anion (ONOO-), a strong oxidant which can initiate reactions characteristic of hydroxyl radical (HO.), nitronium ion (NO2+) and nitrogen dioxide radical (NO2.). Peroxynitrite, therefore, may cause DNA or tissue damage, contributing to the multistage carcinogenesis process. We have studied reactions of various bases, nucleosides or deoxynucleosides with peroxynitrite in vitro. Guanine… CONTINUE READING

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