Formation of 8-S-L-cysteinylguanosine from 8-bromoguanosine and cysteine.

  title={Formation of 8-S-L-cysteinylguanosine from 8-bromoguanosine and cysteine.},
  author={Toshinori Suzuki and Aya Kosaka and Michiyo Inukai},
  journal={Bioorganic \& medicinal chemistry letters},
  volume={23 13},
When 8-bromoguanosine was incubated with cysteine at pH 7.4 and 37 °C, a previously unidentified product was formed as a major product in addition to guanosine. The product was identified as a cysteine substitution derivative of guanosine at the 8 position, 8-S-L-cysteinylguanosine. The reaction was accelerated under mildly basic conditions. The cysteine adduct of guanosine was fairly stable and decomposed with a half-life of 193 h at pH 7.4 and 37 °C. Similar results were observed for… Expand
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