Formation of 6,13-dihydroxyoctadecatrienoic acid isomers from γ-linolenic acid

@inproceedings{Kim1989FormationO6,
  title={Formation of 6,13-dihydroxyoctadecatrienoic acid isomers from γ-linolenic acid},
  author={Mee Ree Kim and Dai-Eun Sok},
  year={1989}
}
Abstract Incubation of γ-linolenic acid with soybean lipoxygenase initially at pH 9.3 and sibsequently at pH 7.9 gave rise to the conjugated triene dioxygenation product (λ max = 267 nm, > 50% yield), which was reduced to form 9-cis isomer of 6,13-dihydroxyoctadecatrienoic acid (6,13- diHOT) accompanied by minor isomers. Meanwhile, hemoglobin converted 13-hydroperoxyoctadecatrienoic acid into two major 9-trans isomers of 6,13-diHOT and two 9-cis isomers as minor products. The four isomers of 6… CONTINUE READING