Formation and repair of oxidative damage in the mitochondrial DNA.

Abstract

The mitochondrial DNA (mtDNA) encodes for only 13 polypeptides, components of 4 of the 5 oxidative phosphorylation complexes. But despite this apparently small numeric contribution, all 13 subunits are essential for the proper functioning of the oxidative phosphorylation circuit. Thus, accumulation of lesions, mutations and deletions/insertions in the mtDNA… (More)
DOI: 10.1016/j.mito.2014.03.007

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Cite this paper

@article{Muftuoglu2014FormationAR, title={Formation and repair of oxidative damage in the mitochondrial DNA.}, author={Meltem Muftuoglu and Mateus Prates Mori and Nadja Cristhina de Souza-Pinto}, journal={Mitochondrion}, year={2014}, volume={17}, pages={164-81} }