Formation and maintenance of ventilatory long-term facilitation require NMDA but not non-NMDA receptors in awake rats.

@article{McGuire2008FormationAM,
  title={Formation and maintenance of ventilatory long-term facilitation require NMDA but not non-NMDA receptors in awake rats.},
  author={Michelle McGuire and Chun Liu and Ying Cao and Liming Ling},
  journal={Journal of applied physiology},
  year={2008},
  volume={105 3},
  pages={
          942-50
        }
}
N-methyl-d-aspartate (NMDA) receptor antagonism in the phrenic motonucleus area eliminates phrenic long-term facilitation (pLTF; a persistent augmentation of phrenic nerve activity after episodic hypoxia) in anesthetized rats. However, whether NMDA antagonism can eliminate ventilatory LTF (vLTF) in awake rats is unclear. The role of non-NMDA receptors in LTF is also unknown. Serotonin receptor antagonism before, but not after, episodic hypoxia eliminates pLTF, suggesting that serotonin… CONTINUE READING

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