Formation and functions of the corneocyte lipid envelope (CLE).

  title={Formation and functions of the corneocyte lipid envelope (CLE).},
  author={Peter M Elias and Robert Gruber and Debra A. Crumrine and Gopinathan K. Menon and Mary Lou Williams and J. St. John Wakefield and Walter M. Holleran and Yoshikazu Uchida},
  journal={Biochimica et biophysica acta},
  volume={1841 3},
Corneocytes in mammalian stratum corneum are surrounded by a monolayer of covalently bound ω-OH-ceramides that form the corneocyte (-bound) lipid envelope (CLE). We review here the structure, composition, and possible functions of this structure, with insights provided by inherited and acquired disorders of lipid metabolism. This article is part of a Special Issue entitled The Important Role of Lipids in the Epidermis and their Role in the Formation and Maintenance of the Cutaneous Barrier… CONTINUE READING

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