Formation and degradation of deoxyadenosine nucleotides in inherited adenosine deaminase deficiency.

@article{Simmonds1982FormationAD,
  title={Formation and degradation of deoxyadenosine nucleotides in inherited adenosine deaminase deficiency.},
  author={H. Anne Simmonds and Diane R Webster and David Perrett and S. Reiter and Roland J. Levinsky},
  journal={Bioscience reports},
  year={1982},
  volume={2 5},
  pages={303-14}
}
dATP, dADP, and dAMP equalled or exceeded the depleted levels of ATP, ADP, and AMP in erythrocytes from two children with adenosine deaminase (ADA; EC 3.5.4.4) deficiency. dATP and dADP were identified in the mononuclear cells of only one child. The levels of deoxyadenosine compounds fell dramatically after enzyme replacement therapy and were no longer detectable in the urine or in mononuclear cells. Erythrocyte adenosine nucleotide levels showed a corresponding increase. Intact erythrocytes… CONTINUE READING