Formation and branch migration of Holliday junctions mediated by eukaryotic recombinases

@article{Murayama2008FormationAB,
  title={Formation and branch migration of Holliday junctions mediated by eukaryotic recombinases},
  author={Yasuto Murayama and Yumiko Kurokawa and K. Mayanagi and H. Iwasaki},
  journal={Nature},
  year={2008},
  volume={451},
  pages={1018-1021}
}
  • Yasuto Murayama, Yumiko Kurokawa, +1 author H. Iwasaki
  • Published 2008
  • Medicine, Biology
  • Nature
  • Holliday junctions (HJs) are key intermediates in homologous recombination and are especially important for the production of crossover recombinants. Bacterial RecA family proteins promote the formation and branch migration of HJs in vitro by catalysing a reciprocal DNA-strand exchange reaction between two duplex DNA molecules, one of which contains a single-stranded DNA region that is essential for initial nucleoprotein filament formation. This activity has been reported only for prokaryotic… CONTINUE READING

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    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 36 REFERENCES