Formation and analysis of topographical domains between lipid membranes tethered by DNA hybrids of different lengths.

@article{Chung2013FormationAA,
  title={Formation and analysis of topographical domains between lipid membranes tethered by DNA hybrids of different lengths.},
  author={Minsub Chung and Bon Jun Koo and Steven G Boxer},
  journal={Faraday discussions},
  year={2013},
  volume={161},
  pages={333-45; discussion 419-59}
}
We recently described a strategy to prepare DNA-tethered lipid membranes either to fixed DNA on a surface or to DNA displayed on a supported bilayer [Boxer et al., J. Struct. Biol., 2009, 168, 190; Boxer et al., Langmuir, 2011, 27, 5492]. With the latter system, the DNA hybrids are laterally mobile; when orthogonal sense-antisense pairs of different lengths are used, the DNA hybrids segregate by height and the tethered membrane deforms to accommodate the height difference. This architecture is… CONTINUE READING

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