Formation and activation of fibroblast spheroids depend on fibronectin-integrin interaction.

@article{Salmenper2008FormationAA,
  title={Formation and activation of fibroblast spheroids depend on fibronectin-integrin interaction.},
  author={Pertteli Salmenper{\"a} and Esko Kankuri and Jozef B{\'i}zik and Vappu Sir{\'e}n and Ismo Virtanen and Seiichiro Takahashi and Michael Leiss and Reinhard F{\"a}ssler and Antti Vaheri},
  journal={Experimental cell research},
  year={2008},
  volume={314 19},
  pages={3444-52}
}
Clustering of fibroblasts into spheroids induces a massive proinflammatory, proteolytic and growth-factor response, named nemosis, which promotes tumor cell invasiveness and differentiation of leukemia cells. We have now sought to investigate mechanisms leading to the formation of multicellular spheroids and subsequent activation of fibroblasts (nemosis). Cell lines either lacking fibronectin expression (FN-/-) or expressing FN with a mutated integrin-binding site (FNRGE/RGE) were unable to… CONTINUE READING

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Fibronectin at a glance.

Journal of cell science • 2002
View 5 Excerpts
Highly Influenced

Fibroblasts in cancer

Nature Reviews Cancer • 2006
View 5 Excerpts
Highly Influenced

The ins and outs of fibronectin matrix assembly.

Journal of cell science • 2003
View 3 Excerpts
Highly Influenced

Fibronectins

R. O. Hynes
Springer-Verlag Inc, New York • 1990
View 4 Excerpts
Highly Influenced

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