Formation and Maturation of Phase-Separated Liquid Droplets by RNA-Binding Proteins.


Eukaryotic cells possess numerous dynamic membrane-less organelles, RNP granules, enriched in RNA and RNA-binding proteins containing disordered regions. We demonstrate that the disordered regions of key RNP granule components and the full-length granule protein hnRNPA1 can phase separate in vitro, producing dynamic liquid droplets. Phase separation is… (More)
DOI: 10.1016/j.molcel.2015.08.018


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