Formation and Maturation of Phase-Separated Liquid Droplets by RNA-Binding Proteins.

Abstract

Eukaryotic cells possess numerous dynamic membrane-less organelles, RNP granules, enriched in RNA and RNA-binding proteins containing disordered regions. We demonstrate that the disordered regions of key RNP granule components and the full-length granule protein hnRNPA1 can phase separate in vitro, producing dynamic liquid droplets. Phase separation is… (More)
DOI: 10.1016/j.molcel.2015.08.018

Topics

6 Figures and Tables

Slides referencing similar topics