Formation, mineralization, and resorption of bone in hypophosphatemic rats.

@article{Baylink1971FormationMA,
  title={Formation, mineralization, and resorption of bone in hypophosphatemic rats.},
  author={David J. Baylink and Jon E. Wergedal and M E Stauffer},
  journal={The Journal of clinical investigation},
  year={1971},
  volume={50 12},
  pages={2519-30}
}
Quantitative morphologic methods were used to measure the effects of feeding a low phosphorus diet to intact and thyroparathyroidectomized rats on several processes of bone mineralization and turnover. In severely hypophosphatemic animals, the matrix formation rate was decreased, the osteoid maturation rate was decreased, which indicated a delay in the onset of mineralization, the initial rate of mineralization was decreased, and the endosteal osteoclastic bone resorption rate was increased. In… CONTINUE READING