Formation, metabolism, and physiologic importance of catecholestrogens.

  title={Formation, metabolism, and physiologic importance of catecholestrogens.},
  author={P. Ball and Rudolf Knuppen},
  journal={American journal of obstetrics and gynecology},
  volume={163 6 Pt 2},
The metabolism of natural and synthetic estrogens is governed primarily by hydroxylations, leading to polyhydroxylated derivatives of the steroid molecule. In mammals aromatic hydroxylation is most prominent quantitatively. The 2- and 4-hydroxyestrogens (catecholestrogens) formed are secreted not only in high amounts in urine but are also present in significant quantities in different organs, such as the liver, pituitary gland, and hypothalamus. This A ring hydroxylation of primary estrogens is… CONTINUE READING
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