Formation, accumulation and release of adenosine 3',5'-monophosphate induced by histamine in the superior cervical ganglion of the rat in vitro.

@article{Lindl1974FormationAA,
  title={Formation, accumulation and release of adenosine 3',5'-monophosphate induced by histamine in the superior cervical ganglion of the rat in vitro.},
  author={T. Lindl and H. Cramer},
  journal={Biochimica et biophysica acta},
  year={1974},
  volume={343 1},
  pages={
          182-91
        }
}
  • T. Lindl, H. Cramer
  • Published 1974
  • Chemistry, Medicine
  • Biochimica et biophysica acta
  • Abstract 1. 1. Histamine increased endogeneous cyclic AMP levels and the conversion rate of 14 C-labeled adenine nucleotides to cyclic[ 14 C]AMP in rat superior ganglia in vitro in a dose-related manner, with half-maximal stimulation at a concentration of about 2·10 −4 M. 2. 2. The accumulation of cyclic AMP could be blocked by antihistamine drugs. The H 2 -blocker burimanide showed a strong stimulatory effect on adenylate cyclase in contrast to diphenhydramine. Practolol, a β-adrenergic… CONTINUE READING
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