Formation, Regulation and Evolution of Caenorhabditis elegans 3′UTRs

  title={Formation, Regulation and Evolution of Caenorhabditis elegans 3′UTRs},
  author={Calvin H. Jan and Robin C. Friedman and J. G. Ruby and David P. Bartel},
Post-transcriptional gene regulation frequently occurs through elements in mRNA 3′ untranslated regions (UTRs). Although crucial roles for 3′UTR-mediated gene regulation have been found in Caenorhabditis elegans, most C. elegans genes have lacked annotated 3′UTRs. Here we describe a high-throughput method for reliable identification of polyadenylated RNA termini, and we apply this method, called poly(A)-position profiling by sequencing (3P-Seq), to determine C. elegans 3′UTRs. Compared to… CONTINUE READING
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