Formamidopyrimidines in DNA: mechanisms of formation, repair, and biological effects.

  title={Formamidopyrimidines in DNA: mechanisms of formation, repair, and biological effects.},
  author={Miral Dizdaroğlu and G{\"u}ldal Kirkali and Pawel Jaruga},
  journal={Free radical biology & medicine},
  volume={45 12},
Oxidatively induced damage to DNA results in a plethora of lesions comprising modified bases and sugars, DNA-protein cross-links, tandem lesions, strand breaks, and clustered lesions. Formamidopyrimidines, 4,6-diamino-5-formamidopyrimidine (FapyAde) and 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapyGua), are among the major lesions generated in DNA by hydroxyl radical attack, UV radiation, or photosensitization under numerous in vitro and in vivo conditions. They are formed by one-electron… CONTINUE READING


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