Formalin-induced long-term secondary allodynia and hyperalgesia are maintained by descending facilitation.

@article{AmbrizTututi2011FormalininducedLS,
  title={Formalin-induced long-term secondary allodynia and hyperalgesia are maintained by descending facilitation.},
  author={M{\'o}nica Ambriz-Tututi and Silvia Lorenia Cruz and H{\'e}ctor Urquiza-Mar{\'i}n and Vinicio Granados-Soto},
  journal={Pharmacology, biochemistry, and behavior},
  year={2011},
  volume={98 3},
  pages={417-24}
}
This work analyzes the role of cholecystokinin (CCK) receptors, dynorphin A₁₋₁₇ and descending facilitation originated in the rostral ventromedial medulla (RVM) on secondary allodynia and hyperalgesia in formalin-injected rats. Formalin injection (50 μL, 1%, s.c.) produced acute nociception (lasting 1 h) and long-term secondary allodynia and hyperalgesia in ipsilateral and contralateral hind paws (lasting 1-12 days). Once established, intra-RVM administration of lidocaine at day 6, but not at 2… CONTINUE READING

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