Formaldehyde-treated, heat-inactivated virions with increased human immunodeficiency virus type 1 env can be used to induce high-titer neutralizing antibody responses.

@article{Poon2005FormaldehydetreatedHV,
  title={Formaldehyde-treated, heat-inactivated virions with increased human immunodeficiency virus type 1 env can be used to induce high-titer neutralizing antibody responses.},
  author={Betty T M Poon and John F Hsu and V K Gudeman and Irvin S. Y. Chen and Kathie Grovit-Ferbas},
  journal={Journal of virology},
  year={2005},
  volume={79 16},
  pages={10210-7}
}
The lack of success of subunit human immunodeficiency virus (HIV) type 1 vaccines to date suggests that multiple components or a complex virion structure may be required. We hypothesized that the failure of current vaccine strategies to induce protective antibodies is linked to the inability of native envelope structures to readily elicit these types of antibodies. We have previously reported on the ability of a formaldehyde-treated, heat-inactivated vaccine to induce modest antibody responses… CONTINUE READING
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