Formaldehyde exposure induces airway inflammation by increasing eosinophil infiltrations through the regulation of reactive oxygen species production.

@article{Jung2007FormaldehydeEI,
  title={Formaldehyde exposure induces airway inflammation by increasing eosinophil infiltrations through the regulation of reactive oxygen species production.},
  author={Woon-Won Jung and Eun-Mi Kim and Eun-Hee Lee and Hee-Jung Yun and Hyang-Ran Ju and Moon-Jin Jeong and Kwang-Woo Hwang and Donggeun Sul and H Kang},
  journal={Environmental toxicology and pharmacology},
  year={2007},
  volume={24 2},
  pages={174-82}
}
Formaldehyde (FA) is a well-known cytotoxic irritant to the airways, but the mechanism of airway inflammation due to FA has not been clarified. In the present study, C57BL/6 mice were exposed to two concentrations (5 and 10ppm) of FA for 6h/day, 5days/week, for 2 weeks. The FA-exposed mice had much higher number of CCR3(+) eosinophils than control mice, and showed upregulated gene expression of CC-chemokine receptor-3 (CCR3), eotaxin and intercellular adhesion molecules-1 (ICAM-1) as well as an… CONTINUE READING