Formaldehyde-activated Pixantrone is a monofunctional DNA alkylator that binds selectively to CpG and CpA doublets.

@article{Evison2008FormaldehydeactivatedPI,
  title={Formaldehyde-activated Pixantrone is a monofunctional DNA alkylator that binds selectively to CpG and CpA doublets.},
  author={Benny J. Evison and Francis Chi Keung Chiu and Gabriella Pezzoni and Don R. Phillips and Suzanne M. Cutts},
  journal={Molecular pharmacology},
  year={2008},
  volume={74 1},
  pages={
          184-94
        }
}
The topoisomerase II poison mitoxantrone is important in the clinical management of human malignancies. Pixantrone, a novel aza-anthracenedione developed to improve the therapeutic profile of mitoxantrone, can efficiently alkylate DNA after formaldehyde activation. In vitro transcriptional analysis has now established that formaldehyde-activated pixantrone generates covalent adducts selectively at discrete CpG or CpA dinucleotides, suggesting that the activated complex binds to guanine or… CONTINUE READING
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