Formaldehyde, aspartame, and migraines: a possible connection.
@article{Jacob2008FormaldehydeAA, title={Formaldehyde, aspartame, and migraines: a possible connection.}, author={Sharon E Jacob and Sarah A Stechschulte}, journal={Dermatitis : contact, atopic, occupational, drug}, year={2008}, volume={19 3}, pages={ E10-1 } }
Aspartame is a widely used artificial sweetener that has been linked to pediatric and adolescent migraines. Upon ingestion, aspartame is broken, converted, and oxidized into formaldehyde in various tissues. We present the first case series of aspartame-associated migraines related to clinically relevant positive reactions to formaldehyde on patch testing.
Tables from this paper
39 Citations
Systematized Contact Dermatitis and Montelukast in an Atopic Boy
- MedicinePediatric dermatology
- 2009
A 9‐year‐old Caucasian boy with a history of mild atopic dermatitis that experienced severe systematized dermatitis after being started on montelukast chewable tablets containing aspartame is presented.
[Allergic contact dermatitis caused by formaldehyde and formaldehyde releasers].
- MedicineActas dermo-sifiliograficas
- 2011
Systemic Contact Dermatitis in Children: How an Avoidance Diet Can Make a Difference
- MedicinePediatric dermatology
- 2011
A case series of 8 pediatric patients diagnosed with SCD from the contact dermatology clinic showed marked improvement of their dermatitis after adequate dietary avoidance, and common presentations of chemicals causing SCD in children and potential dietary modifications are reviewed.
Mechanistic Insights into Aspartame-induced Immune Dysregulation
- Biology, ChemistryCurrent Nutrition & Food Science
- 2019
Proposed mechanisms for immune dysfunction associated with aspartame include alterations in bidirectional communication between neuro-immune-endocrine responses, disruption of the brain-gut-microbiota-immune axis, and the immune-activation effect of methanol.
144 Contact Dermatitis: Diagnosis and Therapy
- Medicine
- 2012
Data from multiple international tertiary care centers serve as a useful guide in the selection of allergens used for patch testing, especially given that many of the same allergens appear across the lists globally.
Patch Test Clinic Start-up: From Basics to Pearls.
- MedicineDermatitis : contact, atopic, occupational, drug
- 2020
This review focuses on the basics of patch testing and provides practical pearls to assist novice providers in establishing a contact dermatitis specialty practice.
COMMONLY USED ARTIFICIAL SWEETENERS IN EUROPE
- 2021
Despite doubts about the safety of artificial sweeteners, many studies have shown the absence of dangers associated with their use (if used in the acceptable daily intake, ADI).
Contact allergy to formaldehyde. Diagnosis and clinical relevance.
- Medicine
- 2014
Daily exposure to low concentrations of formaldehyde is sufficient to exacerbate existing dermatitis in patients with contact allergy to formaldehyde, and to assess exposure and clinical relevance in formaldehyde-allergic patients, the patients’ skin care products should be analysed.
Neurobehavioral effects of aspartame consumption.
- PsychologyResearch in nursing & health
- 2014
When consuming high-aspartame diets, participants had more irritable mood, exhibited more depression, and performed worse on spatial orientation tests, and aspartame consumption did not influence working memory.
References
SHOWING 1-10 OF 19 REFERENCES
Aspartame: A Safety Evaluation Based on Current Use Levels, Regulations, and Toxicological and Epidemiological Studies
- BiologyCritical reviews in toxicology
- 2007
The data from the extensive investigations into the possibility of neurotoxic effects of aspartame, in general, do not support the hypothesis that aspartam in the human diet will affect nervous system function, learning or behavior.
Systemic contact dermatitis of the eyelids caused by formaldehyde derived from aspartame?
- MedicineContact dermatitis
- 2003
A 60-year-old Caucasian woman presented with a 6-month history of eyelid dermatitis, and within 1 week of discontinuing theaspartame, her eyeliddermatitis resolved completely and has not recurred over 18 months without specific treatment.
Formaldehyde derived from dietary aspartame binds to tissue components in vivo.
- Biology, MedicineLife sciences
- 1998
A biologically based dynamic model for predicting the disposition of methanol and its metabolites in animals and humans.
- BiologyToxicological sciences : an official journal of the Society of Toxicology
- 2001
The model predicts that 8-h inhalation exposures ranging from 500 to 2000 ppm, without physical activities, are needed to increase concentrations of blood formate and urinary formic acid above mean background values reported by various authors (4.9-10.3 and 6.3-13 mg/liter, respectively).
Multimedia environmental goals for environmental assessment. Volume I. Supplement a. Report for October 1978-October 1979
- Environmental Science
- 1980
The report supplements Volume I (PB-276 919) of the two-volume 1977 EPA report that introduced a methodology to establish Multimedia Environmental Goals (MEGs) for chemical pollutants. It summarizes…
Methanol poisoning. A rodent model with structural and functional evidence for retinal involvement.
- MedicineArchives of ophthalmology
- 1991
These studies document direct retinal involvement in this nonprimate model of methanol toxicity and show swelling and disruption of the mitochondria in photoreceptor inner segments, optic nerve, and the retinal pigment epithelium.
Formaldehyde, aspartame, migraines: a possible connection.
- MedicineDermatitis : contact, atopic, occupational, drug
- 2009
Metabolism of aspartame in monkeys.
- Chemistry, MedicineThe Journal of nutrition
- 1973
It was concluded that aspartame was digested to its three constituents that were then absorbed as natural constituents of the diet.