Formal synthesis of chelamidine alkaloids and their derivatives.

  title={Formal synthesis of chelamidine alkaloids and their derivatives.},
  author={Rui-Qi Li and Yu He and Yao Yao Ding and Chee-Kiat Ang and Jie-Sheng Tian and Teck-Peng Loh},
  journal={Chemical communications},
  volume={54 25},
A concise two-step operation of α-amination of aldehydes and subsequent Friedel-Crafts/Prins-type cyclization towards accessing tetrahydrobenzo[c]phenanthridine and related structures was developed. The reaction displayed a broad substrate scope and good tolerance to a variety of substituents such as different aromatic heterocyclic rings. In addition, the effectiveness of this protocol was also demonstrated in the formal synthesis of homochelidonine and chelamidine.