Formal Total Synthesis of Hybocarpone Enabled by Visible-Light-Promoted Benzannulation.

@article{Chen2018FormalTS,
  title={Formal Total Synthesis of Hybocarpone Enabled by Visible-Light-Promoted Benzannulation.},
  author={Wei Chen and Renyu Guo and Z. Yang and Jianxian Gong},
  journal={The Journal of organic chemistry},
  year={2018},
  volume={83 24},
  pages={
          15524-15532
        }
}
The formal total synthesis of hybocarpone was achieved in eight steps from commercially available 1,2,4-trimethoxybenzene. Key transformations include a visible-light-promoted benzannulation to construct the key α-naphthol intermediate and a modified CAN-mediated dimerization/hydration cascade sequence to generate the vicinal all-carbon quaternary centers in a stereocontrolled manner. The total synthesis of boryquinone was also achieved in seven steps. 
3 Citations