Form follows function: Morphological and immunohistological insights into epithelial-mesenchymal transition characteristics of tumor buds.

@article{EnderleAmmour2017FormFF,
  title={Form follows function: Morphological and immunohistological insights into epithelial-mesenchymal transition characteristics of tumor buds.},
  author={Kathrin Enderle-Ammour and Moritz Bader and Theresa Dorothee Ahrens and Kai Franke and Sylvia Timme and Agnes Csan{\'a}di and Jens Hoeppner and Birte Kulemann and Jochen Maurer and Philip T. Reiss and Oliver Schilling and Tobias Keck and T. Brabletz and Elmar Stickeler and Martin Werner and Ulrich F Wellner and Peter Bronsert},
  journal={Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine},
  year={2017},
  volume={39 5},
  pages={1010428317705501}
}
In cancer biology, the architectural concept "form follows function" is reflected by cell morphology, migration, and epithelial-mesenchymal transition protein pattern. In vivo, features of epithelial-mesenchymal transition have been associated with tumor budding, which correlates significantly with patient outcome. Hereby, the majority of tumor buds are not truly detached but still connected to a major tumor mass. For detailed insights into the different tumor bud types and the process of tumor… CONTINUE READING