Form and function in the vascular system

  title={Form and function in the vascular system},
  author={Anja Bondke Persson and Pontus B. Persson},
  journal={Acta Physiologica},
While most peer-reviewed papers published worldwide are signed by a European author, the ratio of EU’s contribution to the 10% most-cited scientific publications lags behind the ratio for the United States (European Commission 2012). Having spent time at a high-ranking US laboratory still constitutes a special accolade for researchers all over Europe in the daily battle for funds and tenure. This is in stark contrast to the incredibly low public knowledge about and acceptance of scientific… 

The Multiple Roles of Pericytes in Vascular Formation and Microglial Functions in the Brain

The function of pericytes is summarized, focusing on the interplay betweenpericytes and microglia, the resident immune cells of the CNS, which colonize the brain at embryonic day (E) 9.5 in mice.

Gr upSM Prosthetic Heart Valves in the Aortic Position : A Review

In this book-chapter the anatomy and structure of the aortic valve and its prostheses are extensively discussed.

Prosthetic Aortic Heart Valves

The anatomy and structure of the aortic valve and its prosthesis are comprehensively discussed and cardiac anatomy and function, human heart valves and their prostheses are also extensively discussed.



Ibn al-Nafis (1210–1288): The First Description of the Pulmonary Circulation

His was the first work to contradict the accepted teachings of Galen and lead to a change in the historical observations that the pulmonary circulation was discovered by European scientists in the 16th century and lead many to wonder if these scientists had access to Ibn al-Nafis’ translated works.

The beauty of the mammalian vascular system

Beauty is a characteristic of objects that provides a perceptual experience of pleasure. In nature, aesthetic appreciation thereof has given rise to the mathematical search for good series (e.g. the

Discovery of the cardiovascular system: from Galen to William Harvey

  • W. Aird
  • Medicine
    Journal of thrombosis and haemostasis : JTH
  • 2011
The goal of this review is to examine the events that led to discovery of blood circulation, and how William Harvey employed experiment and deductive logic to show that arteries and veins are functionally, if not structurally, connected in the lung and the peripheral tissues, and that blood circulates.

Pathophysiology of hypertension in pre‐eclampsia: a lesson in integrative physiology

Despite being one of the leading causes of maternal death and a major contributor of maternal and perinatal morbidity, the mechanisms responsible for the pathogenesis of pre‐eclampsia have yet to be

Renal pericytes: regulators of medullary blood flow

The evidence favouring a physiological role for pericytes in the regulation of MBF is discussed and their potential role in tubulo‐vascular cross‐talk in this region of the kidney is described.

Acute and sustained actions of hyperglycaemia on endothelial and glomerular barrier permeability

Evidence that acute or sustained HG may lead to an increased vascular or glomerular permeability is summarized and activation of protein kinase C, the polyol pathway, and an increased release of reactive oxygen species (ROS) and cytokines could contribute to the increase in barrier permeability induced by HG.

Nutritional programming of the metabolic syndrome

The effect of changes in maternal nutrition during critical windows in fetal development on an individual's subsequent predisposition to the metabolic syndrome is considered.

Novel signalling mechanisms and targets in renal ischaemia and reperfusion injury

This work focuses on signalling mediators, their receptors and intracellular signalling pathways which bear potential to abrogate cellular processes involved in the pathogenesis of I/R‐induced AKI.

Functional characterization of isolated, perfused outermedullary descending human vasa recta

An experimental model of human single isolated, perfused OMDVR is established and their vasoactivity in response to angiotensin II and to pressure changes is characterized.

PPARγ activation inhibits cerebral arteriogenesis in the hypoperfused rat brain

The effect of PPARγ stimulation on cerebral adaptive and therapeutic collateral growth is assessed, which improves cardiovascular (CV) risk factors, but without improving overall clinical outcomes.