Form and function in cell motility: from fibroblasts to keratocytes.

@article{Herant2010FormAF,
  title={Form and function in cell motility: from fibroblasts to keratocytes.},
  author={Marc Herant and Micah Dembo},
  journal={Biophysical journal},
  year={2010},
  volume={98 8},
  pages={1408-17}
}
It is plain enough that a horse is made for running, but similar statements about motile cells are not so obvious. Here the basis for structure-function relations in cell motility is explored by application of a new computational technique that allows realistic three-dimensional simulations of cells migrating on flat substrata. With this approach, some cyber cells spontaneously display the classic irregular protrusion cycles and handmirror morphology of a crawling fibroblast, and others the… CONTINUE READING

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