Forkhead transcription factor FoxO1 in adipose tissue regulates energy storage and expenditure.

@article{Nakae2008ForkheadTF,
  title={Forkhead transcription factor FoxO1 in adipose tissue regulates energy storage and expenditure.},
  author={Jun Nakae and Yongheng Cao and Miyo Oki and Yasuko Orba and H Sawa and Hiroshi Kiyonari and Kristy Iskandar and Koji Suga and Marc Lomb{\`e}s and Yoshitake Hayashi},
  journal={Diabetes},
  year={2008},
  volume={57 3},
  pages={563-76}
}
OBJECTIVE Adipose tissue serves as an integrator of various physiological pathways, energy balance, and glucose homeostasis. Forkhead box-containing protein O subfamily (FoxO) 1 mediates insulin action at the transcriptional level. However, physiological roles of FoxO1 in adipose tissue remain unclear. RESEARCH DESIGN AND METHODS In the present study, we generated adipose tissue-specific FoxO1 transgenic mice (adipocyte protein 2 [aP(2)]-FLAG-Delta 256) using an aP(2) promoter/enhancer and a… CONTINUE READING