Forkhead transcription factor FOXO subfamily is essential for reactive oxygen species-induced apoptosis.

@article{Nakamura2008ForkheadTF,
  title={Forkhead transcription factor FOXO subfamily is essential for reactive oxygen species-induced apoptosis.},
  author={Tomohiro Nakamura and Kazuichi Sakamoto},
  journal={Molecular and cellular endocrinology},
  year={2008},
  volume={281 1-2},
  pages={47-55}
}
Intracellular accumulation of reactive oxygen species is implicated in the pathogenesis of cancer and other diseases by disturbing proper cell cycle control or cell survival. Here, we show that the expression and phosphorylation of FOXO is drastically affected by H(2)O(2) treatment, resulting in drastic induction of luteal cell apoptosis. Western blot analysis revealed that FOXO1a accumulated preferentially in the nucleus upon ROS stimuli, resulting in the transactivation of IRS promoter… CONTINUE READING

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