Forkhead proteins control the outcome of transcription factor binding by antiactivation.

@article{Voth2007ForkheadPC,
  title={Forkhead proteins control the outcome of transcription factor binding by antiactivation.},
  author={Warren Voth and Yaxin Yu and Shinya Takahata and Kelsi L. Kretschmann and Jason D. Lieb and Rebecca Lynn Parker and Brett Milash and David J Stillman},
  journal={The EMBO journal},
  year={2007},
  volume={26 20},
  pages={
          4324-34
        }
}
Transcription factors with identical DNA-binding specificity often activate different genes in vivo. Yeast Ace2 and Swi5 are such activators, with targets we classify as Swi5-only, Ace2-only, or both. We define two unique regulatory modes. Ace2 and Swi5 both bind in vitro to Swi5-only genes such as HO, but only Swi5 binds and activates in vivo. In contrast, Ace2 and Swi5 both bind in vivo to Ace2-only genes, such as CTS1, but promoter-bound Swi5 fails to activate. We show that activation by… CONTINUE READING
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