Forkhead box Q1: A key player in the pathogenesis of tumors (Review).

@article{Li2016ForkheadBQ,
  title={Forkhead box Q1: A key player in the pathogenesis of tumors (Review).},
  author={Yang-Yang Li and Yefei Zhang and Zhendong Yao and Sisi Li and Zhenhua Yin and Min Xu},
  journal={International journal of oncology},
  year={2016},
  volume={49 1},
  pages={
          51-8
        }
}
As a member of the Forkhead box protein family, Forkhead box Q1 (FOXQ1) is a transcription factor that functions to regulate cell differentiation. Recently, an increasing number of studies have demonstrated that FOXQ1 is significantly associated with the pathogenesis of tumors. This review aims to predominantly discuss the relationship between FOXQ1 and various types of tumor. The FOXQ1 gene is located at human chromosome 6p25.3 and encodes a functional 403 amino acid protein, which has many… 
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FOXK transcription factors: Regulation and critical role in cancer.
Novel mechanistic targets of Forkhead box Q1 transcription factor in human breast cancer cells
TLDR
It is shown for the first time that FoxQ1 is a direct transcriptional regulator of interleukin (IL)-1α, IL-8, and vascular endothelial growth factor in breast cancer cells.
The forkhead-box family of transcription factors: key molecular players in colorectal cancer pathogenesis
TLDR
The molecular and functional characteristics of most relevant FOX molecules have been described within the context of CRC biology, including their usefulness regarding diagnosis and prognosis, and potential CRC therapeutics (including genome-editing approaches) involving FOX regulation have also been included.
Melanoma Suppressor Functions of the Carcinoma Oncogene FOXQ1.
FOXQ1 promotes proliferation and metastasis of epithelial ovarian cancer via activation of SIRT1/NRF2 signaling pathway
TLDR
F Forkhead Box Q1 contributes to the progression of epithelial ovarian cancer partly via SIRT1/NRF2 signaling pathway, this highlighting a novel strategy for treating epithel ovarian cancer.
Novel mechanistic targets of forkhead box Q1 transcription factor in human breast cancer cells.
TLDR
It is shown for the first time that FoxQ1 is a direct transcriptional regulator of interleukin (IL)-1α, IL-8, and vascular endothelial growth factor in breast cancer cells as evidenced by chromatin immunoprecipitation assay.
Overexpression of Forkhead box Q1 correlates with poor prognosis in papillary thyroid carcinoma
TLDR
Investigation of whether FOXQ1 is correlated with poor prognosis in PTC found it to be correlated withpoor prognosis.
FOXQ1 controls the induced differentiation of melanocytic cells
TLDR
It is demonstrated that pigmentation induced in cultured melanocytic cells and in mice by activation of cAMP/CREB1 pathway depends in large part on FOXQ1, and that FoxQ1 acts as a critical mediator of BRAFV600E-dependent regulation of MITF levels, thus providing a novel link between two major signal transduction pathways controlling MITF and differentiation in melanocytical cells.
The FoxQ1 transcription factor is a novel regulator of electron transport chain complex I subunits in human breast cancer cells
TLDR
It is proposed that increased complex I‐linked oxidative phosphorylation is partly responsible for oncogenic role of FoxQ1 at least in human breast cancer cells.
The Significance of FOXQ 1 Expression in Papillary Thyroid Carcinoma
TLDR
The results suggested that FOXQ1 might play an oncogenic role in PTC, and was positively correlated to the status of lymphatic metastasis and the stage of TNM in P TC.
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