Forkhead box N4 (Foxn4) activates Dll4-Notch signaling to suppress photoreceptor cell fates of early retinal progenitors.

@article{Luo2012ForkheadBN,
  title={Forkhead box N4 (Foxn4) activates Dll4-Notch signaling to suppress photoreceptor cell fates of early retinal progenitors.},
  author={Huijun Luo and Kangxin Jin and Zhenhui Xie and Feng Qiu and Shengguo Li and Min Zou and Li Cai and Katsuto Hozumi and David T. Shima and Mengqing Xiang},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2012},
  volume={109 9},
  pages={E553-62}
}
The generation of diverse neuronal types and subtypes from multipotent progenitors during development is crucial for assembling functional neural circuits in the adult central nervous system. During mouse retinogenesis, early retinal progenitors give rise to several cell types, including ganglion, amacrine, horizontal, cone, and rod cells. It is unknown at present how each of these fates is selected from the multiple neuronal fates available to the early progenitor. By using a combination of… CONTINUE READING

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