Forkhead box B2 inhibits the malignant characteristics of the pancreatic cancer cell line Panc‐1 in vitro

@article{Fukuchi2019ForkheadBB,
  title={Forkhead box B2 inhibits the malignant characteristics of the pancreatic cancer cell line Panc‐1 in vitro},
  author={Hiroki Fukuchi and Yukinobu Hayashida and Kunio Inoue and Yoshifusa Sadamura},
  journal={Genes to Cells},
  year={2019},
  volume={24},
  pages={674 - 681}
}
Forkhead box (FOX) proteins constitute a family of transcription factors that are evolutionarily conserved in various species ranging from yeast to humans. These proteins have functions during development as well as in adulthood. To date, many reports have described the functions of FOX family genes in cancer cells, but the role of FOXB2 is not well understood. In one of the pancreas ductal adenocarcinoma cell lines, Panc‐1 cells, we showed here that FOXB2 expression is barely detectable and… 
View on Wiley
onlinelibrary.wiley.com
1 Citations

One Citation

Citation Type

Citation Type

Exploration of the System-Level Mechanisms of the Herbal Drug FDY003 for Pancreatic Cancer Treatment: A Network Pharmacological Investigation
TLDR
This work explored the anti-PC properties and system-level mechanisms of the herbal drug FDY003 and found that it decreased the viability of human PC cells and strengthened their chemosensitivity.

References

SHOWING 1-10 OF 35 REFERENCES
Oncogenic function of ATDC in pancreatic cancer through Wnt pathway activation and beta-catenin stabilization.
Concomitant Targeting of Multiple Key Transcription Factors Effectively Disrupts Cancer Stem Cells Enriched in Side Population of Human Pancreatic Cancer Cells
TLDR
The findings indicate that targeting the key genes conferring the stemness of CSCs can efficiently eliminate CSC-like phenotypes, and thus may be considered a new approach for cancer therapy.
Wnt activator FOXB2 drives prostate cancer neuroendocrine differentiation
TLDR
The results suggest that FOXB2 is a tissue-specific Wnt enhancer that promotes prostate cancer malignant transformation and decreases recurrence-free survival.
Transcriptomic and CRISPR/Cas9 technologies reveal FOXA2 as a tumor suppressor gene in pancreatic cancer.
TLDR
FOXA2 is identified as a novel tumor suppressor in pancreatic cancer and it is regulated directly by miR-199a, thereby enhancing the understanding of how microRNAs interplay with the transcription factors to affect pancreatic oncogenesis.
β-Catenin overexpression is associated with gefitinib resistance in non-small cell lung cancer cells.
Comprehensive expression analysis suggests functional overlapping of human FOX transcription factors in cancer.
TLDR
The expression of 39 FOX genes in 48 kinds of cancer was mined from the Gene Expression Atlas database of European Bioinformatics Institute and showed that some FOX genes demonstrate overlapping expression in various cancers, which suggests particular biological functions.
Small interfering RNAs directed against beta-catenin inhibit the in vitro and in vivo growth of colon cancer cells.
TLDR
It is demonstrated that siRNA can target specific factors whose expression is altered in malignancy and may have the potential as a therapeutic modality to treat human cancer.
The Metastatic Potential and Chemoresistance of Human Pancreatic Cancer Stem Cells
TLDR
The isolation of SP cells can be a convenient and effective tool for the study of PDAC CSCs and the ABCG2 transporter is responsible for the SP phenotype in human PDAC cells, and may be a ubiquitous source of drug-resistance in PDAC, but does not confer resistance to gemcitabine.
The Dominant Role of Forkhead Box Proteins in Cancer
TLDR
Some major aspects of FOX transcription factors in association with cancer research such as drug resistance, tumor growth, genomic alterations or drivers of initiation are summarized.
A comprehensive characterization of pancreatic ductal carcinoma cell lines: towards the establishment of an in vitro research platform
TLDR
It is concluded that the proposed ultrastructural grading system combined with the proliferative activity provides a basis for further comparative studies of pancreatic ductal adenocarcinoma cell lines.
...
1
2
3
4
...