Forkhead Homologue in Rhabdomyosarcoma Functions as a Bifunctional Nuclear Receptor-interacting Protein with Both Coactivator and Corepressor Functions*

@article{Zhao2001ForkheadHI,
  title={Forkhead Homologue in Rhabdomyosarcoma Functions as a Bifunctional Nuclear Receptor-interacting Protein with Both Coactivator and Corepressor Functions*},
  author={Holly Hong Zhao and R. Herrera and E. Coronado-Heinsohn and Michael C. Yang and J. Ludes-Meyers and Karen J. Seybold-Tilson and Z. Nawaz and D. Yee and F. Barr and Sami G. Diab and Powel H. Brown and S. Fuqua and C. Osborne},
  journal={The Journal of Biological Chemistry},
  year={2001},
  volume={276},
  pages={27907 - 27912}
}
  • Holly Hong Zhao, R. Herrera, +10 authors C. Osborne
  • Published 2001
  • Biology, Medicine
  • The Journal of Biological Chemistry
In a search for novel transcriptional intermediary factors for the estrogen receptor (ER), we used the ligand-binding domain and hinge region of ER as bait in a yeast two-hybrid screen of a cDNA library derived from tamoxifen-resistant MCF-7 human breast tumors from an in vivo athymic nude mouse model. Here we report the isolation and characterization of the forkhead homologue in rhabdomyosarcoma (FKHR), a recently described member of the hepatocyte nuclear factor 3/forkhead homeotic gene… Expand
Ligand-dependent Interaction of Estrogen Receptor-α with Members of the Forkhead Transcription Factor Family*
TLDR
A novel mechanism of estrogen action that involves regulation of the proapoptotic forkhead transcription factors is suggested that is specific to ERα and was not detected with other ligand-activated steroid receptors. Expand
FoxG1, a member of the forkhead family, is a corepressor of the androgen receptor
TLDR
The data presented suggest that, in addition to repression of transcription by direct binding to DNA, FoxG1 may interact with AR in vivo, thereby targeting its repressor function specifically to sex hormone signaling. Expand
The LIM-only Protein DRAL/FHL2 Interacts with and Is a Corepressor for the Promyelocytic Leukemia Zinc Finger Protein*
TLDR
Evidence of a functional interaction between the promyelocytic leukemia zinc finger protein (PLZF) and DRAL/FHL2 is presented, the first reported incidence of a bona fide FHL protein-mediated corepression and supports the notion of these proteins having a role as coregulators of tissue-specific gene expression. Expand
Novel role of the RET finger protein in estrogen receptor-mediated transcription in MCF-7 cells.
TLDR
This study provides further evidence that coactivation and corepression are integrally linked processes and that RFP is a component of an ESR1 regulatory complex. Expand
Cyclic AMP-induced Forkhead Transcription Factor, FKHR, Cooperates with CCAAT/Enhancer-binding Protein β in Differentiating Human Endometrial Stromal Cells*
TLDR
Results provide the first evidence of regulated expression of FKHR and demonstrate that FK HR has an integral role in PKA-dependent endometrial differentiation through its ability to bind and functionally cooperate with C/EBPβ. Expand
The activating enzyme of NEDD8 inhibits steroid receptor function.
TLDR
Cl cloning and characterization of a cDNA encoding a protein homologous to yeast and human ubiquitin-activating enzyme 3 (Uba3) is reported, demonstrating that the neddylation activity of Uba3 is required for its inhibition of steroid receptor transactivation. Expand
Hepatocyte Nuclear Factor-4 Is a Novel Downstream Target of Insulin via FKHR as a Signal-regulated Transcriptional Inhibitor*
TLDR
Insulin stimulation reversed the repression of HNF-4 transcriptional activity by phosphorylation-sensitive (wild-type) FKHR, but not by phospholylation-deficient FK HR, suggesting that insulin regulates the transcriptionalactivity of H NF-4 via FKhr as a signal-regulated transcriptional inhibitor. Expand
The role of hepatocyte nuclear factor-3 alpha (Forkhead Box A1) and androgen receptor in transcriptional regulation of prostatic genes.
TLDR
It is found that hepatocyte nuclear factor-3alpha (HNF-3 alpha), an endoderm developmental factor, is essential for androgen receptor (AR)-mediated prostatic gene activation and this data support a model in which regulatory cues from the cell lineage and the extracellular environment coordinately establish the prostatic differentiated response. Expand
Androgens Negatively Regulate Forkhead Transcription Factor FKHR (FOXO1) through a Proteolytic Mechanism in Prostate Cancer Cells*
TLDR
This work demonstrates that forkhead transcription factor FKHR (FOXO1)-induced death of LNCaP cells was blocked by a synthetic androgen R1881, and suggests that androgens induce increased activity of an acidic cysteine protease, which in turn cleaves FK HR. Expand
Expression of the Forkhead Transcription Factor FOXP1 Is Associated with Estrogen Receptor α and Improved Survival in Primary Human Breast Carcinomas
TLDR
The findings support a role for FOXP1 as a potential ER coregulator in human breast carcinoma and suggest that it may also independently regulate additional important pathways that control the progression of breast cancer. Expand
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