Forkhead Box Protein A2 (FOXA2) Protein Stability and Activity Are Regulated by Sumoylation

@inproceedings{Belaguli2012ForkheadBP,
  title={Forkhead Box Protein A2 (FOXA2) Protein Stability and Activity Are Regulated by Sumoylation},
  author={Narasimhaswamy S. Belaguli and Mao Zhang and Francis Charles Brunicardi and David H. Berger},
  booktitle={PloS one},
  year={2012}
}
The forkhead box protein A2 (FOXA2) is an important regulator of glucose and lipid metabolism and organismal energy balance. Little is known about how FOXA2 protein expression and activity are regulated by post-translational modifications. We have identified that FOXA2 is post-translationally modified by covalent attachment of a small ubiquitin related modifier-1 (SUMO-1) and mapped the sumoylation site to the amino acid lysine 6 (K6). Preventing sumoylation by mutating the SUMO acceptor K6 to… CONTINUE READING
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