Forkhead Box Protein 1 (FoxO1) Inhibits Accelerated β Cell Aging in Pancreas-specific SMAD7 Mutant Mice.

Abstract

The mechanisms underlying the effects of exocrine dysfunction on the development of diabetes remain largely unknown. Here we show that pancreatic depletion of SMAD7 resulted in age-dependent increases in β cell dysfunction with accelerated glucose intolerance, followed by overt diabetes. The accelerated β cell dysfunction and loss of proliferation capacity… (More)
DOI: 10.1074/jbc.M116.770032

Topics

Cite this paper

@article{Xiao2017ForkheadBP, title={Forkhead Box Protein 1 (FoxO1) Inhibits Accelerated β Cell Aging in Pancreas-specific SMAD7 Mutant Mice.}, author={Xiangwei Xiao and Congde Chen and Ping Guo and Ting Zhang and Shane Fischbach and Joseph Fusco and Chiyo Shiota and Krishna L. Prasadan and Henry H. Dong and George K. Gittes}, journal={The Journal of biological chemistry}, year={2017}, volume={292 8}, pages={3456-3465} }