Forging forward with 10 burning questions on FGF23 in kidney disease.

@article{Wolf2010ForgingFW,
  title={Forging forward with 10 burning questions on FGF23 in kidney disease.},
  author={Myles Wolf},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2010},
  volume={21 9},
  pages={1427-35}
}
The discovery of fibroblast growth factor 23 (FGF23) as the causal factor in the pathogenesis of rare forms of hypophosphatemic rickets is rapidly reshaping our understanding of disordered mineral metabolism in chronic kidney disease (CKD). Excessive production of FGF23 by osteocytes is an appropriate compensation to help maintain normal phosphorus metabolism in these patients. Beginning in early CKD, progressive increases in levels of FGF23 enhance phosphaturia on a per-nephron basis and… CONTINUE READING
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