Forging a signature of in vivo senescence

Abstract

'Cellular senescence', a term originally defining the characteristics of cultured cells that exceed their replicative limit, has been broadened to describe durable states of proliferative arrest induced by disparate stress factors. Proposed relationships between cellular senescence, tumour suppression, loss of tissue regenerative capacity and ageing suffer… (More)
DOI: 10.1038/nrc3988

Topics

Cite this paper

@article{Sharpless2015ForgingAS, title={Forging a signature of in vivo senescence}, author={Norman E Sharpless and Charles J Sherr}, journal={Nature Reviews Cancer}, year={2015}, volume={15}, pages={397-408} }