Forging T-Lymphocyte Identity: Intersecting Networks of Transcriptional Control.


T-lymphocyte development branches off from other lymphoid developmental programs through its requirement for sustained environmental signals through the Notch pathway. In the thymus, Notch signaling induces a succession of T-lineage regulatory factors that collectively create the T-cell identity through distinct steps. This process involves both the staged… (More)
DOI: 10.1016/


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