Forest plot as a tool to demonstrate the pharmaceutical potential of plants in a tropical forest of Panama

  title={Forest plot as a tool to demonstrate the pharmaceutical potential of plants in a tropical forest of Panama},
  author={Angela I. Calder{\'o}n and Cindy K. Angerhofer and John M. Pezzuto and N. R. Farnsworth and Robin B. Foster and Richard S. Condit and Mahabir P Gupta and D. D. Soejarto},
  journal={Economic Botany},
Based on literature analysis of 308 angiosperm species inventoried from a 50-hectare forest plot on Barro Colorado Island, Panama, 40 species were selected and 80 samples (two samples for every species; leaf + twig and stembark samples) were collected for investigation of their medicinal/pharmaceutical potential. Extracts of these 80 samples were tested in bioassay systems to assess cancer chemoprevention (eight assays), antiplasmodial, cytotoxicity, and anti-HIV activities. Details of bioassay… 

Tables from this paper

Identification of Antibacterial Phenolics in Selected Plant Species from Mexican Cloud Forest by Mass Spectrometry Dereplication
The findings confirm for the first time the value of the CF plants from Veracruz as sources of bioactive natural products with antimicrobial properties against phytopathogenic bacteria.
Evidence for conservation and sustainable use in a fragment of the Atlantic forest in southeastern Brazil by a traditional human group
The results corroborate the hypothesis that richness of a plant family is a predictive character of its cultural importance and the community recognizes the value of conserving the forest remnants and the degree of recognition of taxa by the local specialists nor their use-versatility depended on their abundance in nature.
The good and the bad: Alkaloid screening and brineshrimp bioassays of aqueous extracts of 31 medicinal plants of eastern Nicaragua
Twenty-five of the ethnomedicines contain alkaloids but are not cytotoxic, suggesting that the majority of effective medicinals should be expected to be noncytotoxic.
Avaliação da mutagenicidade in vivo e in vitro de compostos obtidos de plantas nativas do cerrado
The use of medicinal plants is a common practice in our country as well as in several other regions of the planet. However, many plants represent in its chemical constitution compounds that represent
But What About the Forest? Mature Forests and Highland Maya Medicinal Plants
Economic arguments have been made to justify conservation of tropical mature forests. These forests are assumed to be rich in potential pharmaceuticals and medicinal plants. Conservationists and
Maclura tinctoria Extracts: In Vitro Antibacterial Activity against Aeromonas hydrophila and Sedative Effect in Rhamdia quelen
Maclura tinctoria is a tree species native from Brazil and rich in phenolic compounds. Since plant antibacterial activity is highly associated with phenolic compound concentration, we aim to evaluate
Effects of oral administration of crude leaf extracts of Aglaia loheri Blanco and Ardisia pyramidalis (Cav.) Pers on mouse embryo morphology and maternal reproductive performance
It is suggested that caution must be taken when taking these extracts during pregnancy due to their possible toxicity and teratogenicity, and their effects on maternal reproductive performance and fetal morphology.
Screening of plants with antimicrobial activity against enterobacteria, Pseudomonas spp. and Staphylococcus spp.
It is demonstrated that Mouriri elliptica and Buchenavia tomentosa were the most active plants against the studied bacteria.
Extraction of plant secondary metabolites.
This chapter presents an overview of the preparation of extracts from plants using organic solvents, with emphasis on common problems encountered and methods for their reduction or elimination. In
In-Vivo Toxicity Assessment of Stem Bark Extracts of Spondias mombin (Linn) on Male and Female Albino Rats
The use of the stem bark extracts of S.mombin is relatively safe in rats, and acute toxicity test carried out showed that stem bark Extracts of Spondias mombin did not produce mortality in rats.


Costaricine, a new antiplasmodial bisbenzylisoquinoline alkaloid from Nectandra salicifolia trunk bark.
A MeOH extract of Nectandra salicifolia trunk bark, obtained during a diversity-based plant collection in a lower montane rainforest in Costa Rica, showed activity in an in vitro antiplasmodial assay
Biodiversity prospecting and benefit-sharing: perspectives from the field.
  • D. Soejarto
  • Biology, Medicine
    Journal of ethnopharmacology
  • 1996
The effort to search and develop a biologically active compound(s) from natural sources is a long-term process that involves teamwork between field and laboratory scientists, and the success of the endeavor will depend in large part on the continued flow of raw material from the field.
Cytotoxic and antimalarial alkaloids from the tubers of Stephania pierrei.
Comparison of the alkaloid content of S. pierrei and Stephania erecta strongly suggested separate identities for the two plants, and cytotoxic and antimalarial activity was found.
Tropical rain forest
There have been several recent regional accounts which partly or wholly deal with rain forest and its environment. These include three important syntheses for Amazonia (Hemming, 1985a; 1985b; Prance
Isolation and structure elucidation of ardisenone: a new, cytotoxic alkenylphenol from Ardisia iwahigensis.
A novel alkenylphenol, (Z)-1,16-bis(3-hydroxy-5-methoxyphenyl)-10-hexadecene-1,15-dione (ardisenone) (1), was isolated from the extract by bioassay-directed fractionation and demonstrated moderate cytotoxicity against BC1, Lu1, Col2, KB, KB-V1, and LNCaP cell lines.
Rapid detection of inducers of enzymes that protect against carcinogens.
The assay system permits not only rapid detection of inducers of anticarcinogenic enzymes in the human diet but also elucidation of effects of storage and processing on inducer activities.
Short-term dynamics of a neotropical forest: why ecological research matters to tropical conservation and management
Arguments that ecological research on species-rich tropical forests is too little, too late, an irrelevancy, and a luxury we can ill afford when time is running out to save tropical forests are
Quantitative assessment of antimalarial activity in vitro by a semiautomated microdilution technique.
A rapid, semiautomated microdilution method was developed for measuring the activity of potential antimalarial drugs against cultured intraerythrocytic asexual forms of the human malaria parasite Plasmodium falciparum, and results demonstrated that the method is sensitive and precise.
New colorimetric cytotoxicity assay for anticancer-drug screening.
The SRB assay provides a sensitive measure of drug-induced cytotoxicity, is useful in quantitating clonogenicity, and is well suited to high-volume, automated drug screening.
Natural Product Cancer Chemopreventive Agents
Primary prevention strategies, including cessation of cigarette smoking, reduction of exposure to chemical carcinogens), elements such as early diagnosis, dietary modification, and cancer training programs will need to be emphasized.