Foreshortened Dorsal Extension of the Central Sulcus in Williams Syndrome

  title={Foreshortened Dorsal Extension of the Central Sulcus in Williams Syndrome},
  author={Andrea Parolin Jackowski and Robert T. Schultz},

Brain abnormalities in Williams syndrome: a review of structural and functional magnetic resonance imaging findings.

Anomalous sylvian fissure morphology in Williams syndrome

MRI Assessment of Superior Temporal Gyrus in Williams Syndrome

Atypical patterns of asymmetry and reduced STG volume in WS were observed, which may contribute to some of the linguistic impairments found in this cohort of WS patients.

The neurobiology of Williams syndrome: Cascading influences of visual system impairment?

It is suggested that people with WS have a primary impairment in neural systems that support the performance of space-based actions, and hemizygosity for the transcription factor II-I gene family probably affects the development of visual systems and Lim-kinase 1 hemIZygosity exacerbates the impairments in performing space- based actions.

Understanding Neuropsychiatric Disorders: Neuroimaging of Williams–Beuren syndrome

This chapter reviews imaging studies delineating the unique neuropsychiatric features of Williams-Beuren syndrome (WS), as well as recent advances in investigating the neural substrates of the

Correlación fenotipo neuroanatómico y neurocognitivo en el síndrome de Williams

Differences in the pattern of association between cognitive and br ain measures suggest altered neurodevelopmental patterns in WS.

Alterations in diffusion properties of white matter in Williams syndrome.

Research Review: Williams syndrome: a critical review of the cognitive, behavioral, and neuroanatomical phenotype.

The need for methodologically sound studies that utilize multiple comparison groups, developmental trajectories, and longitudinal analyses to examine the WS phenotype is highlighted, as well as those that link brain structure and function to the cognitive and behavioral phenotype of WS individuals.

Language and communication abnormalities in Williams Syndrome and Schizophrenia : Event-related potentials (ERP) evidence

Language and communication abnormalities are a hallmark of both Williams Syndrome (WS) and Schizophrenia. Both disorders represent atypical developmental pathways, in which the complexity of the



Dorsal forebrain anomaly in Williams syndrome.

Anomalies in the dorsal region in patients with WMS are indicative of early neurodevelopmental problems affecting the development of the dorsal forebrain and are most likely related to the deficits in visuospatial ability and behavioral timing often observed in this condition.

IV. Neuroanatomy of Williams Syndrome: A High-Resolution MRI Study

Assessment of tissue composition indicated that, relative to controls, individuals with WMS have relative preservation of cerebral gray matter volume and disproportionate reduction in cerebral white matter volume, and the right occipital lobe was noted to have excess volume loss.

Williams syndrome: neuronal size and neuronal-packing density in primary visual cortex.

Cell measurements differ in peripheral visual cortical fields of Williams syndrome, with significantly smaller, more closely packed cells in some layers on the left side, and neuronal size differences may be related to visuospatial deficits in this population.

Corpus callosum morphology of Williams syndrome: relation to genetics and behavior

As the largest interhemispheric commissure in the brain, the corpus callosum is of particular interest in disorders that may preferentially affect white matter development such as Williams syndrome

Specific neurobehavioral profile of Williams' syndrome is associated with neocerebellar hemispheric preservation

The first in vivo volumetric study of any structure within the cerebellar hemispheres is presented, identifying and reliably measured the neocerebellar tonsils in Williams' syndrome subjects; Down's syndrome subjects matched for age, IQ, and cerebral volume; and age-matched normal controls.

Analysis of cerebral shape in Williams syndrome.

Subjects with WMS have significantly different cerebral shape from normal controls, perhaps due to decreased parieto-occipital lobe volumes relative to frontal regions and similar observation in the corpus callosum may be associated with a decreased size of the splenium in WMS.

Morphology and morphometry of the corpus callosum in Williams syndrome: A T1-weighted MRI study

High-resolution T1-weighted MRI of the brain of 12 patients with WS and 12 normal control subjects were used to estimate the shape and volume of the corpus callosum, as well as the voxel intensity values as a measure its water content, indicating an aberrant development of the CC in patients withWS.

Increased gyrification in Williams syndrome: evidence using 3D MRI methods.

Results suggest that one or more genes in the 7q11.23 region are involved during the critical period when cortical folding occurs, and may be related to the hypothesized dorsal/ventral dissociation in this condition.

Cerebellar abnormalities in infants and toddlers with Williams syndrome.

The results lead us to suggest that abnormal cerebellar enlargement is evident in those with Williams syndrome at an early age, leading to the suggestion that the cerebellum may play a role in cognition.

Cerebral morphologic distinctions between Williams and Down syndromes.

The results suggest that some frontal and temporal limbic structures are relatively preserved in WS, while some basal ganglia and diencephalic structure are relatively preservation in DS.