Forensic ancestry analysis in two Chinese minority populations using massively parallel sequencing of 165 ancestry‐informative SNPs

  title={Forensic ancestry analysis in two Chinese minority populations using massively parallel sequencing of 165 ancestry‐informative SNPs},
  author={Guanglin He and Zheng Wang and Mengge Wang and Tao Luo and Jing Liu and You Zhou and Bo Gao and Yiping Hou},
Ancestry inference based on SNPs with marked allele frequency differences in diverse populations (called ancestry‐informative SNP (AISNP)) is rapidly developed with the technology advancements of massively parallel sequencing. Despite the decade of exploration and broad public interest in the peopling of East‐Asians, the genetic landscape of Chinese Silk Road populations based on the AISNPs is still little known. In this work, 206 unrelated individuals from Chinese Uyghur and Hui populations… 
Massively parallel sequencing of 165 ancestry-informative SNPs and forensic biogeographical ancestry inference in three southern Chinese Sinitic/Tai-Kadai populations
Ancestry composition and multiple phylogenetic analysis demonstrated that the geographically isolated Qiongzhong Hlai harbored a close phylogenetic relationship with Austronesian speakers and possessed a homogenous Tai-Kadai-dominant ancestry, which could be used as the ancestral source proxy in population history reconstruction ofTai-KADai-speaking populations and as one of the representatives for forensic database establishment.
Ancestry Prediction Comparisons of Different AISNPs for Five Continental Populations and Population Structure Dissection of the Xinjiang Hui Group via a Self-Developed Panel
The ancestry resolutions of the 30 AISNPs and the other previously reported AISNP panels for African, European, East Asian, South Asian and American populations were compared and genetic relationship analyses among the studied HUI group demonstrated that the Hui group had close genetic affinities with East Asian populations and might share the genetic ancestries with EastAsian populations.
Genetic Structural Differentiation Analyses of Intercontinental Populations and Ancestry Inference of the Chinese Hui Group Based on a Novel Developed Autosomal AIM-InDel Genotyping System
The results indicated that the Hui group was genetically closer to East Asian populations, especially two Chinese Han populations (CHS and CHB populations), and the AIM-InDel panel could well reveal the genetic structural differentiations of the East Asian, European, African, and South Asian populations.
Forensic characterization and genetic polymorphisms of 19 X-chromosomal STRs in 1344 Han Chinese individuals and comprehensive population relationship analyses among 20 Chinese groups
The comprehensive population comparisons reveal that Han Chinese is a homogenous population and has the genetically closer relationship with Hmong-Mien-speaking groups than Tibetan-Burman-speaking and Turkic-speaking populations.
The Genetic Structure of Chinese Hui Ethnic Group Revealed by Complete Mitochondrial Genome Analyses Using Massively Parallel Sequencing
The results demonstrated that Hui group exhibited closer genetic relationships with Chinese Han populations from different regions, which was largely attributable to the widespread of haplogroups D4, D5, M7, B4, and F1 in these populations.
Forensic features and genetic structure of the Hotan Uyghur inferred from 27 forensic markers
The findings not only reveal that Chinese Uyghur is a homogenous population based on forensic genetic markers, but also indicate that population genetic affinity is closely related to the adjacent populations with common ethnic origin.


Analyses of a set of 128 ancestry informative single-nucleotide polymorphisms in a global set of 119 population samples
The simultaneous importance of the specific set of population samples and their relative sample sizes in the use of the structure program to determine which groups cluster together and consequently influence the ability of a marker panel to infer ancestry is demonstrated.
Multi-InDel Analysis for Ancestry Inference of Sub-Populations in China
The panel consisting of multi-InDel markers exhibited considerable potency in ancestry inference, and was suggested to be applied in forensic practices and genetic population studies.
Detecting a hierarchical genetic population structure via Multi-InDel markers on the X chromosome
It is proposed that a multi-insertion-deletion polymorphism (Multi-InDel) with multiple haplotypes can be useful in ancestry inference and hierarchical genetic population structures.
Ancestry informative marker sets for determining continental origin and admixture proportions in common populations in America
It is concluded that investigators can use TaqMan assays for the selected AIMs as a simple and cost efficient tool to control for differences in continental ancestry when conducting association studies in ethnically diverse populations.
Increasing the reference populations for the 55 AISNP panel: the need and benefits
Ancestry inference for an individual can only be as good as the reference populations with allele frequency data on the SNPs being used. If the most relevant ancestral population(s) does not have
Forensic genetic analysis of bio-geographical ancestry.
  • C. Phillips
  • Biology
    Forensic science international. Genetics
  • 2015