• Chemistry, Medicine
  • Published in
    Drug metabolism and…
    1988

Foreign compound metabolism studies with human liver obtained as surgical waste. Relation to donor characteristics and effects of tissue storage.

@article{Powis1988ForeignCM,
  title={Foreign compound metabolism studies with human liver obtained as surgical waste. Relation to donor characteristics and effects of tissue storage.},
  author={Garth Powis and Ian D. Jardine and Russell Van Dyke and R Weinshilboum and Ds Moore and Thomas Wilke and William Rhodes and Robert L. Nelson and Lars Benson and Carol L. Szumlanski},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={1988},
  volume={16 4},
  pages={
          582-9
        }
}
An investigation has been conducted on the foreign compound-metabolizing activity of human liver collected fresh from surgery or at autopsy from cadavers 3 to 18 hr old, and the effects of low temperature storage on the foreign compound-metabolizing activity of fresh human liver. The enzyme activities studied were microsomal cytochrome P-450 content, biphenyl 4-hydroxylation, benzo-(a)pyrene metabolism, halothane reduction, and 4-hydroxybiphenyl UDP-glucuronosyl transferase, as well as… CONTINUE READING

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